Age related changes in bone marrow mesenchymal stromal cells

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Effects include a potential impact on osteoporosis and osteoarthritis development. 

Ganguly P, J J, V P, N A, Ponchel F, A E.

Ageing at the cellular level is a complex process resulting from accumulation of various damages leading to functionalimpairment and a reduced quality of life at the level of the organism. With a rise in the elderly population, the worldwide incidence of osteoporosis (OP) and osteoarthritis (OA) has increased in the past few decades. A decline in the number and fitness of osteoblast progenitors, the mesenchymal stromal cells (MSCs) in the bone marrow (BM) niche has been suggested as one of the factors contributing to bone abnormalities in OP and OA. It is well-recognised that MSCs acquire culture-induced ageing features such as gradual telomere shortening, increased numbers of senescent cells and reduced resistance to oxidative stress, as a result of serial population doublings. In contrast, there is only limited evidence that human BM MSCs similarly in vivo. This review compares the various aspects of in vitro and in vivo MSC ageing and suggests how our current knowledge on rejuvenating cultured MSCs could be applied to develop future strategies to target altered bone formation processes in OP and OA.


Cell Transplant, 20 de enero de 2017



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